Should obese people who are metabolically healthy be advised to lose weight?
Risk of type 2 diabetes, heart disease and cancer all increase with excess body fat. Yet research has identified two unique groups: those who are obese but metabolically healthy, and those who are a healthy weight but metabolic unhealthy. This was the topic of a session I especially looked forward to attending at last month’s American Diabetes Association Scientific Sessions.
Metabolic health matters when it comes to cancer. Inflammation and the elevated insulin levels that come with insulin resistance are believed to promote cancer development.
Metabolically healthy obesity (MHO) refers to people who have a body mass index (BMI) of 30 or more (for someone who is 5’6” tall, weight of at least 186 pounds) yet don’t have the metabolic abnormalities that typically accompany obesity. There’s not yet a standard definition for MHO, but usually a person with MHO has no more than one of the following: diabetes, high blood pressure, elevated blood triglycerides or low HDL cholesterol. Studies generally report from 3 to 20 percent of obese people meet criteria to be classified as metabolically healthy. Continue reading