Preventing Endometrial Cancer: Talking with Elisa Bandera

The new AICR/World Cancer Research Fund report on preventing endometrial cancer was published today – the report found obesity, coffee, and activity links to risk. The report analyzed the global research on diet, activity, and weight to the risk of endometrial cancer. Here, Elisa Bandera, MD, PhD, the panel lead of this CUP report and an epidemiologist at Rutgers Cancer Institute of New Jersey, talks about the report’s findings and what it means.Bandera_Elisa_small

Q: This is the first systematic update of the research on lifestyle and endometrial cancer risk since 2007. Overall, what’s new here?

A: For the update, we now have more prospective data for dietary factors and interesting associations emerged with coffee consumption and glycemic load. Coffee consumption was associated with reduced risk while glycemic load increased risk. There is also growing evidence that longer sitting time increases endometrial cancer risk.

Q: But the research for sitting time – sedentary livingwas not strong enough to make a conclusion.

A: There were only three studies at this time but they all suggested increased risk. We could not be certain based on the limited data that the association was independent of BMI. However, sitting time has been emerging as an important risk factor for other cancers, independent of physical activity. In other words, it is not sufficient to go to the gym three times a week. We have to remember to get up out of our chairs and move and avoid extended period of sittings in front of the television or the computer.

Q: How much more research is there now on endometrial cancer prevention compared to the last report?

A: There are more studies, but particularly more prospective studies evaluating dietary factors, which were lacking in the first report.  Still, only few prospective studies have evaluated some of the dietary exposures and endometrial cancer risk compared to the number of studies that have evaluated them in relation to breast or colorectal cancers.

Q: Why is having prospective data so important?

A: The previous report’s conclusions were based on mainly findings from case-control studies, which are generally considered weaker than cohort or prospective studies. Continue reading


Study: Antioxidants from Our Coffee and Diet May Cut Prostate Cancer Risk

Research now shows that men can reduce their risk of prostate cancer by eating foods containing lycopene and selenium, two phytochemicals that act as antioxidant in our body. Now a large new study that suggests men get over a quarter of their antioxidants from coffee has found that consumingCoffeeBeansCup_dreamstime_13158097_smallplenty of antioxidants from our diet has a weak link to reduced prostate cancer risk.

The study – supported in part by AICR – was published in the International Journal of Cancer last week.

For the study, almost 48,000 men answered questions about what they ate, drank and the supplements they took, starting in 1986 and then every four years. Researchers calculated antioxidant intake by assigning a value to each food or supplement.

Overall, coffee was supplying the men with 28 percent of their total antioxidants; fruits and vegetables were giving the men 23 percent; and dietary supplements another 23 percent. Continue reading


More Hot Research: Coffee May Lower Risk of Oral Cancer

Hot on the heels of AICR’s latest summary of the evidence on coffee and cancer risk in our Foods that Fight Cancer, a new study published this week found that drinking coffee – with caffeine – may help protect against death from oral/pharyngeal cancers.

Published in the American Journal of Epidemiology the researchers report a strong association for lower risk from caffeinated coffee. The link for decaffeinated coffee was weaker, though suggested some benefit. They found no association for tea. Continue reading