Enhancing Ovarian Cancer Treatment with Plant Compounds

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One of the big challenges in cancer treatment is resistance, when cells never react or stop reacting to a chemotherapy drug’s lethal effects. For ovarian cancer, resistance can occur with the commonly-used drug cisplatin.

The phytochemicals found in plant foods may help, a new study suggests. The study is preliminary, conducted on cancer cells, yet it suggests that a phytochemical called kaempferol may help this ovarian treatment be more effective.

Kaempferol is a flavonoid, one of the largest groups of phytochemicals and studied previously for its role in protecting against cancer. It’s found in many plant-foods, including berries, tea, and broccoli.

You can read the study here.

AICR has funded many studies on the effects of dietary components on cancer treatments: We featured a couple of them on breast cancer treatment in this months eNews.


    A Heavier Plate for Cancer Prevention?

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    Of the days’ worth of food below, which do you think would be more filling?

    The food on the right is certainly more colorful and offers a lot more to eat than the few choices on the left.

    A new AICR review of the research on calorie (or energy) density and weight loss has found that diets low in calorie density can play an important role in efforts to achieve and maintain a healthy weight.

    The photo above is a great example of how calorie density works. Both 1575 calories, the food on the right contains more low calorie-dense foods – fewer calories, but more food weight.

    Low calorie dense foods, such as fruits and non-starchy vegetables have a lot of water, so by filling up on these, you satisfy your hunger, but eat fewer calories.

    Read more about how to make your plate heavier, but with fewer calories.

    The AICR brochure More Food, Fewer Calories contains strategies on following a low-calorie dense diet along with more information on the health benefits.

    After you’ve tried some of these ideas, share your successes with us.

    Photos: Dr. Barbara Rolls, Penn State University, used with permission.


      Reducing Your Risk of Pancreatic Cancer

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      Pancreatic cancer is one of the leading causes of cancer-related deaths because it is often diagnosed only in its advanced stages.  This week, two new studies on pancreatic cancer suggest there are lifestyle habits that can prevent this disease.

      Source: NCI. Unfortunately, incidence (and mortality) have changed little in recent years.

      The first study, highlighted in today’s issue of Cancer Research Update, supports findings from AICR’s expert report linking higher body weight and waist circumference to increased risk. The study used pooled data from a major National Cancer Institute group of participants, which included about 4,400 individuals – half with the disease and half without. You can read more about the study in CRU.

      The second study linked heavy alcohol use and binge drinking to increased risk of pancreatic cancer in men. Previous research has produced conflicting findings on the alcohol-pancreatic cancer link.

      But this study – which you can read here – found that the more men drank, the higher their increased risk. This held true even if the men consumed the alcoholic drinks years or decades prior to diagnosis. The study included about 500 individuals with the cancer and 1,700 controls, and the participants reported their history of alcohol consumption. There was no connection between alcohol consumption and pancreatic cancer risk among women.

      AICR’s expert report found that foods containing folate — such as beans, leafy greens, and peanuts — probably protect against pancreatic cancer. Want to add some folate to your day? Spinach will help. Try making AICR’s Turkey, Spinach and Apple Wrap.